After the death of Achyuta Raya in AD 1541, his son Venkatadri or Venkata-I ascended the throne, but could not reign long, and within six months the crown was passed to the nephew of Achyuta - Sadasiva. Sadasiva Raya was a mere puppet in the hand of his minister Rama Raya of the Aravidu dynasty. Rama Raya was able to restore the power of Vijayanagara, which had sunk after Krishna Devaraya's rule. The important policy of Rama Raya was to interfere in the quarrels among the Deccan Sultanates, in alliance first with one, and then with another.
He indeed was successful for the time being. This made him over confident and ultimately proved fatal. Meddling into the affairs of the Muslim states led to the combining of all the Muslim states against the Hindus and the combined forces faced each other in the Battle of Talikota. It was one of the most decisive battles in Indian history like the Panipat and the battle of Plassey. Hopes of Hindus were totally shattered with the defeat and the south India was once again opened for Muslim penetration till Marathas slowly rose to power.